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General Hospital: Spoilers For October 2021

Dorathy Gass

September 29, 2021

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Ghost, ghouls, and Cassadines — oh my! October can be a spooky and scary time of year in the land of Port Charles. What’s set to unravel on General Hospital (GH) this month? Sounds like Drew will return to the little town, while there will be some plot twists attached to Sonny’s comeback. Also, Nina finally faces the music! Learn about these and other storylines in the below GH spoilers for October 2021.

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12. Drew Returns

With Anna and Valentin in-the-know about Nurse Chloe, GH spoilers for the coming weeks reveal that their investigation will “ramp up”. Sounds like there is a very good chance that Drew comes back in October, thanks to Devane and Cassadine. What will his return to Port Charles bring? Plenty of happy tears from friends and family, plus a possible romantic reunion.

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11. Drew’s Second Chance At Love

Another major GH spoiler for next month indicates that Drew will get a second chance in the love department. Does this mean that Sam will be open to a reunion? Meanwhile, this could also mean a romantic connection with Nurse Chloe, or someone else. Regardless, Drew’s return might hit Sam hard. He is Scout’s dad, after all.

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10. Sam and Dante

GH spoilers state that Sam and Dante will get closer, early on in October. Their relationship will likely progress to a full-on romance, just in time for Drew to re-appear. The drama is sure to hit a fever pitch once Sam realizes that Scout’s father is alive and well. Considering that she ended things because of Jason, will Drew’s return leave her conflicted now that she’s not with “Stone Cold”?

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9. The Fallout of Sonny’s Return

Speaking of a return, Sonny’s comeback has been explosive. However, the fallout to this storyline is just beginning. GH spoilers hint that Carly will learn “all” about what happened in Nixon Falls in early October. Mrs. Corinthos won’t be overly pleased to learn about Nina’s role in the entire thing. Added teasers for October hint that fans should expect more than a few twists and turns in this storyline.

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8. Nina Faces The Music

GH spoilers for early October suggest that Nina will face the music over her secret in Nixon Falls with “Mike”. But fans know she won’t only face “repercussions”, she’ll face the wrath of Carly Corinthos. Could Carly, Michael and Willow decide to keep Nina away from Wiley indefinitely? After all, Reeves *technically* kept Wiley away from Sonny (and the rest of his family).

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7. Nina’s Broken

GH spoilers for October also note that Nina will be left “picking up the pieces” of her life. Not only will she deal with Carly’s wrath and a possible cut-off from Wiley, but she may also encounter shaming from the rest of the Corinthos clan, including Michael and Willow, Kristina, Dante, Josslyn and Jason. She may feel like the town pariah. Will Nina have anyone to turn to?

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6. Nikolas Is Left Heartbroken

GH spoilers for early October suggest that Nikolas will deal with a broken heart. Added teasers imply that he’ll be both stunned and disappointed over something Spencer has done. Will the truth be revealed about Ava’s stalker? Will Esme be implicated in any of this? Sounds like Spence will take the fall on this, alone.

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5. Esme Celebrates

Added GH spoilers note that Esme will do some celebrating when the truth is revealed. Could she set things up so Spencer is implicated in Ava’s stalker case, and she is not? She must know that if this happens, she could lose Cassadine for good. How will she be able to pull off something like this, without getting in trouble?

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4. Secrets Are Revealed

GH spoilers for October state that Esme’s secrets will be uncovered soon. Will fans finally learn what connection she has to Port Charles? Is she linked to Ryan/Kevin, or connected to Ava in some way? What exactly is her story? Sounds like viewers will find out exactly what Esme is about sometime next month.

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3. A Renewed Focus

In other Esme spoilers for October, she may turn her attention to Cam. Will she and Spencer break up after the truth comes out? GH teasers note that Esme will reach out to Cameron for help. As time passes, he and Josslyn won’t see eye-to-eye on something. Could Esme come between Joss and Cam?

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2. Peter Makes An Enemy In Victor

GH spoilers for this month reveal that Peter August is set to make even more enemies — one of them being Victor Cassadine. Sounds like Peter will give Victor an ultimatum, early on in October. In other related teasers, Cassadine will make a stunning discovery. What will he uncover, and does this have to do with Liesl?

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1. The Quartermaines

GH spoilers for early October indicate that Austin will continue his fight for a piece of the Quartermaine fortune. Meanwhile, BLQ might see the error of her ways, as she’ll apologize to the good doctor at some point this month. In other news, Ned and Olivia will continue to struggle with a new issue in their marriage. Sounds like Olivia may not budge on Leo seeing some specialists.

Dorathy Gass

Dorathy Gass is an avid fan of daytime drama and has been watching Days of Our Lives, General Hospital, and Young and the Restless for over two decades now. As a full-time freelance writer, she gets to combine her love of soap operas and writing through her Fame 10 articles. Also a mother of two busy girls and a mommy blogger, she's been published multiple times over in Huffington Post Parents and Scary Mommy.