After 12 seasons of Grey’s Anatomy, fans have seen a lot of different combinations of couples on the show. It seems everyone has dated everyone and there have been a lot of relationships to sift through. As to be expected, fans rooted for some relationships and hoped for the demise of others. It would be nearly impossible to list all of the relationships and couples on Grey’s Anatomy, but there are a few that just stood out, either for good or bad reasons. Check out our roundup of popular couples on Grey’s Anatomy ranked!
14. Izzie Stevens and George O’Malley
Grey’s Anatomy fans that are in the show for the long haul are still haunted by the disaster of a couple that was Izzie Stevens and George O’Malley. For way too long, George pined over Izzie and had fans really believing that once they finally got together actual sparks would fly. Because of this buildup, the let-down of the relationship was even worse than expected. For starters, there was zero physical chemistry between the two which made it not only uncomfortable for them, but awkward for audiences to watch, and of course there is always the fact it happened after George had married Callie, making it an awkward, home-wrecking relationship.