Grey’s Anatomy’s 11 Worst Chemistry Couples

  
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Grey’s Anatomy has seen a lot of drama thanks to a creative team of writers and a revolving cast of characters’ coming in and out of the doors at Seattle Grace (Grey-Sloan Memorial) Hospital. With a a twelfth season going strong, the show has gone through a lot of hook-ups, relationships and marriages and it seems nearly every character has hooked up with every other character, creating a complicated and lengthy list of Grey’s couples. While some pairs were meant to be and had fans cheering for them every step of the way, other couples were almost cringe-worthy to watch and had viewers just wishing the storyline would stop because the characters were so bad together. With so many variations of couples on the show, there is no way every one of them would work, and these 11 were the absolute worst.

11. Alex and Ava/Rebecca

In all fairness, it was a little hard to decide if there actually could be something between Alex Karev and his patient Ava/Rebecca due to her mental state, but from what fans saw, there was no room for chemistry. Alex had always been a carefree womanizer, and while he had a soft side, there was no way this relationship was going to end up in a good place and didn’t seem to work from the beginning. There had been believable relationships between the doctors and patients before, but unfortunately this pairing just wasn’t one of them.

Source: ABC

Source: ABC

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10. Callie and Mark

Both Callie Torres and Mark Sloan were amazing additions to Grey’s Anatomy and, while we appreciated their love for each other as friends, their hook-ups made no sense. They had great chemistry as the best of friends, but their sexual relationship made the best friend status weird and the fact they platonically had a baby, no matter how adorable or well handled, was awkward. These two were great to watch together except for when it came to the casual hook-ups.

Vivian Zink / © ABC / Courtesy: Everett Collection

Vivian Zink / © ABC / Courtesy: Everett Collection

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